pseudo-parkinsonism may occur and in rare instances may persist
Thorazine advertisement, 1966.
Hospital & Community Psychiatry, Vol. 17, No. 10.

for severely psychotic patients where you want fast results
Assaultive, destructive, denudative patients who need effective tranquilizing and need it fast. Head-bangers, screamers, biters and other disruptive types.
Regressed patients with a time-hardened shield of apathy and withdrawal.
In a study of 36 highly psychotic patients... "Remarkable improvement... within... 1 to 3 days."
for patients who get side effects from high doses of single tranquilizers
Need greater therapeutic effect than low doses of one tranquilizer -- hypersensitive to possible side effects from high doses.
In 22 patients... "truly remarkable reduction of side effects."
for patients who need different drug effects at different times of day
'Stelazine' in the morning calms without sedating. 'Thorazine' at night reduces hyperactivity plus gently sedating. "Each drug providing a specific effect to good advantage."
for mental defectives who are behavior problems
Hostile aggressiveness (fighting, kicking, slapping); passive aggressiveness (stubbornness, obstructionism); filthy habits (excretory soiling, coprophagy).
60-year-old female... "first time... ever... employable."
Used in more than 250,000 patients   ~   Thorazine brand of chlorpromazine & Stelazine brand of trifluoperazine combined
Precautions: For use in patients who are hospitalized or under adequate supervision. Potentiation of C.N.S. depressants may occur (reduce dosage of C.N.S. depressants
when used concomitantly.) Antiemetic effect may mask other conditions. Possibility of drowsiness should be borne in mind for patients who drive cars, etc.
In pregnancy, use only when necessary to the welfare of the patient. Use with caution in patients with angina or impaired cardiovasculary systems.
Prolonged administration of high doses may result in accumulative effects with severe C.N.S. or vasomotor symptoms.
Side effects: Occasionally dry mouth; nasal congestion; constipation; amenorrhea; mild fever; hypotensive effects, sometimes severe with I.M. administration;
epinephreine effects may be reversed; dermatological reactions; neuromuscular (extrapyramidal) symptoms (motor restlessness, dystonias, pseudo-parkinsonism) may occur
and, in rare instances, may persist; weight gain; miosis; lactation and moderate breast engorgement (in females on high dosages); insomnia; dizziness; muscular weakness;
anorexia; and less frequently jaundice. Rarely mydriasis; agranulocytosis; skin pigmentation, lenticular and corneal deposits (after prolonged substantial dosages).
Smith Kline & French Laboratories SKF

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