parkinsonism-like symptoms on high dosages in rare instances may persist
Thorazine advertisement, 1967.
Hospital & Community Psychiatry, Vol. 18, No. 9.

Remember these?     About 13 years ago, Thorazine® brand of chlorpromazine helped make them obsolete.
Even more important, it helped to eliminate or modify delusions and hallucinations, lessen confusion, and make the patient
more amenable to other forms of therapy.
In psychiatry, 'Thorazine' remains today's most widely prescribed ataractic.
Before prescribing, please see the complete prescribing information, including side effects reported with phenothiazine derivatives and symptoms and treatment of overdosage, in SK&F literature or PDR. The following is a brief precautionary statement.
Contraindications: Comatose states or the presence of large amounts of C.N.S. depressants. Precautions: Potentiation of C.N.S. depressants may occur (reduce dosage of such agents when used concomitantly). Antiemetic effect may mask signs of overdosage of toxic drugs or obscure diagnosis of other conditions. Administer in pregnancy only when necessary for patient's welfare. Possibility of drowsiness should be kept in mind for patients who drive cars, etc. Side Effects: Drowsiness; dry mouth; nasal congestion; constipation; amenorrhea; miosis; mild fever; weight gain; hypotensive effects, sometimes severe with I.M. administration; epinephrine effects may be reversed; dermatological reactions; parkinsonism-like symptoms on high dosages (in rare instances, may persist); lactation and moderate breast engorgement (in females on high dosages); and less frequently, cholestatic jaundice (use cautiously in patients with liver disease). Side effects occurring rarely include: mydriasis; agranulocytosis; skin pigmentation; lenticular and corneal deposits (after prolonged substantial doses). Available: Tablets -- 10 mg., 25 mg., 50 mg., 100 mg. and 200 mg. Ampuls -- 1cc. and 2cc. (25mg./cc). Multiple-dose Vials -- 10 cc. (25mg./cc). Spansule® capsules -- 30 mg., 75 mg., 150 mg., 200 mg. and 300 mg. Concentrate -- 30 mg./cc.
Smith, Kline & French Laboratories, Philadelphia   SK&F

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