extrapyramidal reactions from chlorpromazine may confuse the diagnosis
Thorazine advertisement, 1982.
Hospital & Community Psychiatry, Vol. 33, No. 6.

Tortured minds and shackled limbs -- common conditions from an era past. The era before the introduction of 'Thorazine', an event that was to revolutionize psychiatric care.
Back in 1954, 'Thorazine' was notable for its effective control of the manifestations of psychosis, for increasing patient accessibility to psychotherapy, for helping restore large numbers of patients to productive lives in the community.
Today, 28 years later, it still is.
THORAZINE® brand of chlorpromazine.
From SK&F, pioneers in psychopharmacology.
Indications: For the management of manifestations of psychotic disorders. To control the manifestations of the manic type of manic-depressive illness. For the treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability and poor frustration tolerance.
Based on a review of this drug by the National Academy of Sciences -- National Research Council and/or other information, FDA has classified the other indication as follows.
Possibly effective For control of excessive anxiety, tension and agitation as seen in neuroses
Final classification of the less-than-effective indication requires further investigation

[Warnings include]
The possibility of extrapyramidal reactions from chlorpromazine may confuse the diagnosis of Reye's syndrome or other encephalopathy. Therefore avoid use in children or adolescents with suspected Reye's syndrome.
[Adverse reactions include]
neuromuscular (extrapyramidal) reactions; pseudo-parkinsonism, motor restlessness, dystonias, persistent tardive dyskinesia.
Smith Kline &French Laboratories     Philadelphia, Pa.     © SmithKline Corporation, 1982

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