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Thorazine advertisement, 1962. Psychosomatics, Vol. 3, No. 6. brand of chlorpromazine THORAZINE® an agent you can rely on for weeks, months – or years Because it is rapidly – often spectacularly – effective, 'Thorazine' has long been regarded an agent of choice in the treatment of acute agitation. The dramatic results obtained in such conditions should not, however, obscure the fact that 'Thorazine' can evoke an equally satisfactory response in moderately disturbed patients who may require treatment for prolonged periods of time. Winkelman's(1) experience with 1090 patients over a six year span illustrates three important features of long-term therapy with 'Thorazine': 'Thorazine' is effective for weeks, months – or years, if necessary. "The therapeutic results in 75 patients who have taken ['Thorazine'] for six years were excellent; nearly all remained symptom-free during the entire period." 'Thorazine' is a useful adjunct to psychotherapy. "Long-term ['Thorazine'] therapy is an extremely valuable and sensitive treatment... in the approachable chronic psychotic and more approachable psychoneurotic, where it can be used as a constructive force furthering the psychotherapeutic process." 'Thorazine' is well tolerated by a great majority of patients. "No patient showed complications after 4-5 months of treatment except mild consistent weight gain (which reached a maximum and did not increase further). The blood counts and blood chemistry were normal throughout. Of the 1090 patients treated, there were 7 cases of clinical liver involvement, all within the first 4½ months of treatment. 'Thorazine' – for prompt and prolonged control of agitation For prescribing information, please see PDR or available literature. Smith Kline & French Laboratories, Philadelphia leaders in psychopharmaceutical research 1. Winkelman, N.W., Jr.: A Long-Term Investigation of Chlorpromazine: A Study of Constant and Inconstant Chlorpromazine Administration Over a Period of Six Years With a Discussion of the Evolution of Our Theoretical Thinking, Am.J. Psychiat. 116:865 (Apr.) 1960. SK&F |