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Thorazine advertisement, 1967. Hospital & Community Psychiatry, Vol. 18, No. 7. Arnold spits it into the toilet. Betty hides it under papers in the wastebasket. Charlie simply refuses it. Some patients pretend to take medication, but later get rid of it because they think they're being poisoned. Others throw away their tablets because they think it's a good way to get back at the nurses who have "been mean" to them. Still others simply balk at taking medication because they're "sick and tired of being pushed around." In these cases, and in many others, the reasons for prescribing 'Thorazine' are also very good reasons for specifying THORAZINE® brand of trifluoperazine CONCENTRATE (primarily for hospital use) -- 30 mg./cc., in 4 fl. oz. bottles, in cartons of 36 bottles and in 1 gallon bottles. Before prescribing, see the complete prescribing information, including side effects reported with phenothiazine derivatives and symptoms and treatment of overdosage, in SK&F literature or PDR. The following is a brief precautionary statement. Contraindications: Comatose states or the presence of large amounts of C.N.S. depressants. Precautions: Potentiation of C.N.S. depressants may occur (reduce dosage of such agents when used concomitantly). Antiemetic effect may mask signs of overdosage of toxic drugs or obscure diagnosis of other conditions. Administer in pregnancy only when necessary for patient's welfare. Possibility of drowsiness should be kept in mind for patients who drive cars, etc. Side Effects: Drowsiness; dry mouth; nasal congestion; constipation; amenorrhea; miosis; mild fever; weight gain; hypotensive effects, sometims severe with I.M administration; epinephrine effects may be reversed; dermatological reactions; parkinsonism-like symptoms on high dosages (in rare instances, may persist); lactation and moderate breast engorgement (in females on high dosages); and less frequently, cholestatic jaundice (use cautiously in patients with liver disease). Side effects occurring rarely include: mydriasis; agranulocytosis; skin pigmentation; lenticular and corneal deposits (after prolonged substantial doses). SK&F ~ Smith Kline & French Laboratories |