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Cogentin advertisement, 1965. Mental Hospitals, Vol. 16, No. 1. Tranquilizer-induced extrapyramidal reactions: For most patients, prompt control Injection Cogentin® Mesylate (benztropine mesylate) normally provides quick relief of alarming dystonic reactions to tranquilizers.(1) When Cogentin is coadministered orally, therapy with phenothiazine or Rauwolfia drugs can usually be continued, often without reduction in dosage.(1,2) Cogentin relieves tranquilizer-induced insomnia, agitation, and turbulence; acute motor restlessness and bizarre neuromuscular symptoms; rigidity, tremors, weakness, and drooling.(1,2) INDICATIONS: Parkinson's disease; extrapyramidal reactions to phenothiazines or reserpine. CONTRAINDICATIONS: None reported. PRECAUTIONS: Supervision of patients is required. In severe reactions, discontinue drug or reduce dosage. Use caution in hot weather to minimize risk of anhidrosis. SIDE EFFECTS: These may be both anticholinergic and antihistaminic. Possible untoward reactions, usually dose-related, include: dryness of mouth, blurred vision, glaucoma, vomiting, anhidrosis, muscular weakness, numbness of fingers, rash, dysuria, urinary retention, constipation, sedation, depression, mental confusion, excitement. Before prescribing or administering, read product circular with package or available on request. SUPPLIED: 0.5 mg. scored tablets in bottles of 100 and as 2 mg. quarterscored tablets, bottles of 100 and 1000. Injection, ampuls of 2 cc., boxes of six. Each cc. contains 1 mg. benztropine mesylate; 9 mg. sodium chloride; and water for injection, q.s. ad 1 cc. REFERENCES: 1. Ayd, F.J., Jr.: J.A.M.A. 175:1054, 1961. 2. Kline, N.S.: Postgrad. Med. 27:620, 1960. COGENTIN benztropine mesylate ~ For parkinsonism, dyskinesia, akathisia Merck Sharp & Dohme ~ where today's theory is tomorrow's therapy Division of Merck & Co.. Inc., West Point, Pa. |