Artane advertisement, 1964.|
Mental Hospitals, Vol. 15, No. 9.
when the bizarre movements are drug-induced parkinsonism     ARTANE trihexyphenidyl hydrochloride
Phenothiazine-induced extrapyramidal symptoms may be brought under prompt control by adding Artane trihexyphenidyl hyrdrochloride... while the primary therapy is continued without interruption.(1,2) Often, the patient may be maintained on as little as half a 2 mg. tablet daily; in other cases, 5 to 15 mg. daily may be needed.
Effective in all forms of Parkinsonism, including phenothiazine/reserpine-induced central nervous system disorders. Your choice of three forms: Tablets, 2 mg. and 5 mg.; Sequels® Sustained Release Capsules, 5 mg.; Elixir, 2 mg./5 cc. tsp.
Side effects: dryness of mouth, blurring of vision, dizziness, mild nausea, or nervousness, which tend to lessen or disappear as treatment continues. Patients with arteriosclerosis or a history of drug idiosyncrasies may exhibit mental confusion, agitation, nausea, or vomiting.
Contraindications: none, but patients with hypertension, as well as cardiac, liver or kidney disorders, should be observed regularly. Incipient glaucoma may be aggravated.
1. Brooks, G. W.: Experience wit the Use of Chlorpromazine and Reserpine in Psychiatry; with Especial Reference to the Significance and Management of Extrapyramidal Dysfunction. New Engl. J. Med. 254:1119 (June 14) 1956.
2. Sarwer-Foner, G. J.: Recognition and Management of Drug-Induced Extrapyramidal Reactions and "Paradoxical" Behavioural Reactions in Psychiatry. Canad. Med. Ass. J. 83:312 (Aug. 13) 1960.
Lederle Laboratories, A Division of American Cyanamid Company, Pearl River, N.Y.