prevents and controls drug-induced parkinsonism
Tremin advertisement, 1964.
Mental Hospitals, Vol. 15, No. 7.

New from Schering to maintain phenothiazine therapy without extrapyramidal interruption
TREMIN(TM) HCl brand of trihexyphenidyl hydrochloride   prevents and controls drug-induced parkinsonism
relaxes muscle rigidity promptly ~ minimizes or obliterates tremor ~ improves mental outlook
Clinical Consideration: Side Effects and Precautions -- Some patients may exhibit minor side effects such as dryness of mouth, blurring of vision, dizziness, mild nausea or nervousness. With continued use of the drug, these side effects tend to decrease. Patients with a history of drug idiosyncrasies or arteriosclerosis may exhibit more severe reactions of mental confusion, agitation or nausea with vomiting. Patients with hypertension, cardiac, kidney, or liver disorders should be observed carefully. Incipient glaucoma may be precipitated. Tremin (trihexyphenidyl) HCl is indicated in all forms of parkinsonism and to prevent and control extrapyramidal disorders due to CNS drugs such as reserpine and the phenothiazines. The usual starting dose is 1 mg. the first day. This may be gradually increased to a total daily dosage of between 5 mg. and 15 mg. administered in divided doses, 3 or 4 times a day at mealtimes. Tremin (trihyxyphenidyl) HCl is available in 2 mg. and 5 mg. scored tablets. For further details, consult Schering literature available from your Schering Representative or Medical Services Dept., Schering Corporation, Union, N.J.

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