delusions hallucinations and paranoia have been reported
Artane advertisement, 1970
Hospital & Community Psychiatry, Vol. 21, No. 8.

She's going steady... with her phenothiazine tranquilizer
Because of ARTANE.   High levels of phenothiazine tranquilizers calmed her considerably. But she began showing signs of drug-induced Parkinsonism -- rigid muscles, a shuffling walk, tremor at rest, thick speech. Artane Trihexiphenidyl HCl helped control her symptoms without risking a setback taking away the benefits of her tranquilizer.   Artane -- Fundamental in the total management of phenothiazine-induced extrapyramidal disorders.
Precautions -- Patients with cardiac, liver or kidney disorders or with hypertension should be maintained under close observation. In long-term therapy, take care to avoid allergic and other untoward reactions. Use with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts and in elderly males with possible prostatic hypertrophy. Geriatric patients require strict dosage regulation. Incipient glaucoma may be precipitated.
Side Effects -- Such effects as dryness of mouth, blurring of vision, dizziness, nausea or nervousness will be experienced by 30 to 50 per cent of patients. (These tend to lessen and can often be controlled by adjusting dosage.) Isolated instances of suppurative parotitis, skin rashes, dilatation of the colon, paralytic ileus, delusions, hallucinations and paranoia have been reported. Patients with arteriosclerosis or with a history of idiosyncrasy to drugs may exhibit mental confusion, agitation, disturbed behavior, or nausea and vomiting. If a severe reaction occurs, discontinue drug for a few days, then resume at lower dosage. Psychiatric disturbances can result from overdosage to sustain euphoria. Side effects of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilatation of the pupil, increased intraocular tension, weakness, vomiting and headache.
Artane® Sequels® Trihexyphenidyl HCl   Sustained Release Capsules 5 mg Tablets: 2 mg and 5mg scored Elixir: 2 mg / 5 cc (Lime-mint Flavor)
Lederle Laboratories, A Division of American Cyanamid Company, Pearl River, New York

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