she began showing signs of drug-induced Parkinsonism
Artane advertisement, 1971.
Hospital & Community Psychiary, Vol. 22, No. 6.

Drug-induced Parkinsonism can affect the young
She's an institutionalized schizophrenic. She'd been making excellent progress while on high levels of a phenothiazine. Then she began showing signs of drug-induced Parkinsonism.
Artane Trihexiphenidyl HCl helped control her extrapyramidal symptoms while her tranquilizer was controlling her schizophrenia. No withdrawal. No risk of setback.
Artane -- Fundamental in the total management of phenothiazine-induced extrapyramidal disorders.
Precautions -- Patients with cardiac, liver or kidney disorders or with hypertension should be maintained under close observation. In long-term therapy, take care to avoid allergic and other untoward reactions. Use with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts and in elderly males with possible prostatic hypertrophy. Geriatric patients require strict dosage regulation. Incipient glaucoma may be precipitated.
Side Effects -- Such effects as dryness of mouth, blurring of vision, dizziness, nausea or nervousness will be experienced by 30 to 50 per cent of patients. (These tend to lessen and can often be controlled by adjusting dosage.) Isolated instances of suppurative parotitis, skin rashes, dilatation of the colon, paralytic ileus, delusions, hallucinations and paranoia (one doubtful case) have been reported. Patients with arteriosclerosis or with a history of idiosyncrasy to drugs may exhibit mental confusion, agitation, disturbed behavior, or nausea and vomiting. If a severe reaction occurs, discontinue drug for a few days, then resume at lower dosage. Psychiatric disturbances can result from overdosage to sustain euphoria. Side effects of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular tension, weakness, vomiting and headache.
Artane® Sequels®   Trihexyphenidyl HCl   Sustained Release Capsules 5 mg
Lederle Laboratories     A Division of American Cyanamid Company     Pearl River, New York

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