risk factors: poor insight and delusional ideas or beliefs, such as thinking that medication is poison
Janssen advertisement, 2006.
Psychiatric News, Vol. 41, No. 14.

PARTIAL COMPLIANCE a hidden danger in schizophrenia
Look for the following risk factors:
*   A history of relapse and rehospitalization (1-3)
*   Poor insight (1,4,5)
*   Disorganized thinking (4,5)
*   Cognitive impairment (4,5)
*   Delusional ideas or beliefs, such as thinking that medication is poison (4)
*   A history of drug or alcohol abuse (4-7)
*   A tendency to discontinue medication when feeling better (4)
Any one of these may mean your patient is at risk for partial compliance.
Partial compliance can lead to serious consequences. (2,5,8)   Don't wait to take action!
References: 1. Ayuso-Gutierrez JL, del Rio Vega JM. Factors influencing relapse in the long-term course of schizophrenia.Schizophr Res. 1997;28:199-206. 2. Csernansky JG, Schuchart EK. Relapse and rehospitalisation rates in patients with schizophrenia: effects of second generation antipsychotics. CNS Drugs. 2002;16:473-484. 3. Lam YWF, Velligan D, Ereshefsky L, et al. Intra-individual variability in plasma concentrations as an indicator of adherence in schizophrenia. Poster presented at 42nd Annual New Clinical Drug Evalution Unit (NCDEU) Meeting June 10-13, 2002; Boca Raton, Fla. 4. Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002;63:892-909. 5. Weiden PJ, Zygmunt A. The road back: working with the severely mentally ill. Medication noncompliance in schizophrenia: part 1. Assessment. J Pract Psychiatry Behav Health. 1997;106-110. 6. Gilmer TP, Dolder CR, Lacro JP, et al. Adherence to treatment with antipsychotic medication and health care costs among Medicaid beneficiaries with schizophrenia. Am J Psychiatry. 2004;161:692-699. 7. Hunt GE, Bergen J, Bashir M. Medication compliance and comorbid substance abuse in schizophrenia: impact on community survival 4 years after a relapse. Schizophr Res. 2002;54:253-264. 8. Weiden PJ, Kozma C, Grogg A, Locklear J. Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia. Psychiatr Serv. 2004;55:886-891.
© Janssen, L.P. 2006

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