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Premarin advertisement, 1975. JAMA: the Journal of the American Medical Association, Vol. 233, No. 6, pp. 498-500. When women outlive their ovaries... "There we were – my husband at the peak of his career – busy, successful... but no time for me. With that and all my other problems, I'd lie awake night after night, more depressed every day. This wasn't a 'change,' it was a catastrophe." Here, illustration shows artist's interpretation of cross section of brain symbolizing impulse transmissions from hypothalamic area to the pituitary and other neurohormonal target organs. Because some emotional symptoms may simply coincide with the menopause, it is essential to distinguish them from those symptoms which are related to estrogen deficiency – and to begin appropriate therapy. "I was always so irritable... snapping at the children... almost anything could annoy me. I knew I was doing it, but I just couldn't seem to stop myself." It's axiomatic that the menopause carries its own burden of physical and emotional problems, some related to ovarian decline, some not. The first step in identifying the source of emotional symptoms is to obtain a thorough history; emotional problems of recent origin are more likely to be related to estrogen deficiency than those of long standing. Then, to distinguish those symptoms that will respond to estrogen replacement therapy from those that may require other approaches to treatment, institute a therapeutic trial with PREMARIN. In many cases, prolonged use of tranquilizers will not be necessary; patients taking PREMARIN alone often report relief of emotional symptoms when these are due to estrogen deficiency... and an improved sense of well-being. Thus, the benefits of PREMARIN in such patients are threefold: it can help relieve symptoms related to estrogen deficiency; help treat the underlying cause; and finally, help identify symptoms unrelated to estrogen deficiency. For the emotional symptoms of the menopause related to estrogen deficiency PREMARIN® (Conjugated Estrogens Tablets, U.S.P.) contains natural estrogens exclusively See last page of advertisement for prescribing information (For full prescribing information, see package circular.) Ayerst Laboratories New York, N.Y. 10017 |