Unlike other antidepressants, Ritalin usually brings relief with the very first dose. Woman sitting on vacuum cleaner.
Ritalin advertisement, 1970
Canadian Family Physician, Vol. 16, No. 5, on back cover.

Ritalin gently overcomes mild depression and the fatigue so often associated with it. This is one agent that really brightens mood and improves performance, helps restore alertness, enthusiasm, and drive. Patients often report that fatigue and worry seem to vanish; they are able to go all day without becoming tired.
Acts in minutes   Unlike other antidepressants, Ritalin usually brings relief with the very first dose. Your patients need not wait days or even weeks to begin feeling better. Ritalin also...
Offers outstanding safety   Unlike amphetamines, Ritalin rarely affects blood pressure or heart rate. It has not been associated with muscle tremors or urinary retention as have the potent MAO inhibitors or tricyclic compounds. And toxic or adverse effects on blood, urine, liver or kidney function are not to be anticipated. For these reasons, Ritalin...
Proves especially valuable for the elderly   This time-tested agent is well tolerated, even by older patients. It rarely affects appetite or causes rebound depression.
Dosage   Oral: Initially, two 10-mg. tablets in the morning, one at noon, and one more, if necessary, at 5:00 p.m. For maintenance, revise as needed.
Side-effects   Nervousness or insomnia, if present, can be avoided by dosage-reduction or by omitting Ritalin in the afternoon. Reports note a few cases of anorexia, dizziness, headache, palpitations, drowsiness, skin rash, overt psychotic behavior and psychic dependency.
Cautions   Not recommended for severe depressions, except in hospital under close supervision. Patients with agitation may react adversely. Use cautiously in the presence of marked anxiety or tension. Ritalin may potentiate the effect of pressor agents; exercise care in use with epinephrine, levarterenol, or angiotension amide. While oral Ritalin has little or no effect on normal blood pressure, use cautiously in patients who have hypertension.
Contraindications   Glaucoma, epilepsy.
Supplied   All forms contain methylphenidate hydrochloride. Tablets of 10 mg. (pale blue, scored); bottles of 100 and 500. Tablets of 20 mg (peach, scored); bottles of 100 and 500. Ampoules of 20 mg. (lyophilized); boxes of 10 and 100.
Helps relieve chronic fatigue and apathy quickly           CIBA       Dorval, Quebec                               0062

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